Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat dams

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Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat dams

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作者：Mary Gemmel^a ; Ine Rayen^b ; Eva van Donkelaar^b ; Tiffany Loftus^a ; Harry W. Steinbusch^b ; Nikolaos Kokras^c ; Christina Dalla^c ; Jodi L. Pawluski^a ; ^b ; ^d ; ^{j.pawluski@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{jodi.pawluski@univ-rennes1.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：5-HIAA ; serotonin&rsquo ; s metabolite ; 5-hydroxyindoleacetic acid ; 5-HT ; serotonin ; DA ; dopamine ; DCX ; doublecortin ; DOPAC ; dopamine&rsquo ; s metabolite dihyroxyphenylacetic acid ; IL ; infralimbic cortex ; NGS ; Normal Goat Serum ; PFC ; prefrontal cortex ; SSRI ; selective serotonin reuptake inhibitor
刊名：Neuroscience
出版年：2016
出版时间：7 July 2016
年：2016
卷：327
期：Complete
页码：32-43
全文大小：767 K

文摘

•: Gestational stress and fluoxetine affect the maternal brain in a region-specific manner.
•: Stress during gestation increases synaptophysin and serotonin in the PFC, but not hippocampus.
•: Fluoxetine reverses the effect of gestational stress on the maternal PFC.
•: Fluoxetine during lactation decreases methylation and serotonin in the maternal hippocampus.

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