Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

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• 作者：Colin Havenar-Daughton¹ ; ² ; Diane G. Carnathan² ; ³ ; Alba Torrents de la Peñ ; a⁵ ; Matthias Pauthner² ; ⁴ ; Bryan Briney² ; ⁴ ; Samantha M. Reiss¹ ; ² ; Jennifer S. Wood³ ; Kirti Kaushik¹ ; ² ; Marit J. van Gils⁵ ; Sandy L. Rosales¹ ; Patricia van der Woude⁵ ; Michela Locci¹ ; ² ; Khoa M. Le² ; ⁴ ; Steven W. de Taeye⁵ ; Devin Sok² ; ⁴ ; Ata Ur Rasheed Mohammed⁶ ; Jessica Huang⁶ ; Sanjeev Gumber³ ; AnaPatricia Garcia³ ; Sudhir P. Kasturi³ ; ⁶ ; Bali Pulendran² ; ³ ; ⁶ ; John P. Moore⁷ ; Rafi Ahmed² ; ⁶ ; Gr&eacute ; gory Seumois¹ ; Dennis R. Burton² ; ⁴ ; ⁹ ; Rogier W. Sanders⁵ ; ⁷ ; Guido Silvestri² ; ³ ; ⁶ ; Shane Crotty¹ ; ² ; ⁸ ; ¹⁰ ; ^{shane@lji.org}
• 关键词：vaccines
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2195-2209
• 全文大小：2570 K
• 卷排序：17

文摘

Fine needle aspirates quantitatively monitor germinal center activity in lymph nodes Neutralizing antibodies correlate with GC B cell magnitude, not ELISA Ab titers Tfh cell quality is associated with vaccine-elicited HIV-neutralizing antibodies LN FNA probing of GCs should be an immune correlate in HIV vaccine trials