Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes

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Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes

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作者：Orane Visvikis¹ ; ⁴ ; Nnamdi Ihuegbu² ; ⁴ ; Sid A. Labed¹ ; Lyly G. Luhachack¹ ; Anna-Maria F. Alves¹ ; Amanda C. Wollenberg¹ ; Lynda M. Stuart³ ; Gary D. Stormo² ; Javier E. Irazoqui¹ ; ^{jirazoqui@mgh.harvard.edu" class="auth_mail}
刊名：Immunity
出版年：19 June 2014
年：2014
卷：40
期：6
页码：896-909
全文大小：2826 K

文摘

•: HLH-30 is a key regulator of the C. elegans transcriptional response to infection
•: HLH-30 induces autophagy and antimicrobial genes required for tolerance of infection
•: TFEB, a murine homolog of HLH-30, is activated during infection in macrophages
•: TFEB is required for proper induction of several cytokines and chemokines

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