Topical application of superoxide dismutase mediated by HIV-TAT peptide attenuates UVB-induced damages in human skin

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Topical application of superoxide dismutase mediated by HIV-TAT peptide attenuates UVB-induced damages in human skin

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作者：Xiaochao Chen^a ; ^b ; Shutao Liu^a ; Pingfan Rao^a ; Jeremy Bradshaw^c ; Richard Weller^b ; ^{r.weller@ed.ac.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：UV ; ultraviolet ; ROS ; reactive oxygen species ; SOD ; superoxide dismutase ; GFP ; green fluorescent protein ; HIV ; human immunodeficiency virus ; TAT ; transactivator of transcription ; CPP ; cell penetrating peptide ; SC ; stratum corneum ; MED ; minimal erythema dose ; SBC ; sunburn cell
刊名：European Journal of Pharmaceutics and Biopharmaceutics
出版年：2016
出版时间：October 2016
年：2016
卷：107
期：Complete
页码：286-294
全文大小：2409 K

文摘

•: Topical application of superoxide dismutase can be enhanced by binding to HIV-TAT peptide.
•: TAT-SOD protein efficiently penetrated through the stratum corneum.
•: TAT-SOD protein significantly attenuated UVB-induced skin damage in man.

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