Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?

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Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?

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作者：Lin Kooi Ong^a ; ^b ; ^c ; Zidan Zhao^a ; ^b ; Murielle Kluge^a ; ^b ; Clifford TeBay^a ; Katarzyna Zalewska^a ; ^b ; Phillip W. Dickson^b ; ^d ; Sarah J. Johnson^e ; Michael Nilsson^a ; ^b ; ^c ; Frederick R. Walker^a ; ^b ; ^c ; ^{rohan.walker@newcastle.edu.au}
关键词：α-Synuclein ; Astrocytes ; Chronic stress ; Microglia ; Neurodegeneration ; Oxidative stress ; Substantia nigra
刊名：Brain, Behavior, and Immunity
出版年：2017
出版时间：February 2017
年：2017
卷：60
期：Complete
页码：117-125
全文大小：2775 K
卷排序：60

文摘

Chronic stress triggers loss of dopaminergic neurons within the substantia nigra. Increased level of oxidative stress. Suppressed glia neuroprotective functions. Enhanced the aggregation of α-synuclein.

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