Amygdala-prefrontal cortical functional connectivity during implicit emotion processing differentiates youth with bipolar spectrum from youth with externalizing disorders

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• 作者：Danella Hafeman^a ; ; Genna Bebko^a ; Michele A. Bertocci^a ; Jay C. Fournier^a ; Henry W. Chase^a ; Lisa Bonar^a ; Susan B. Perlman^a ; Michael Travis^a ; Mary Kay Gill^a ; Vaibhav A. Diwadkar^b ; Jeffrey L. Sunshine^c ; Scott K. Holland^d ; Robert A. Kowatch^e ; Boris Birmaher^a ; David Axelson^g ; Sarah M. Horwitz^f ; L. Eugene Arnold^g ; Mary A. Fristad^g ; Thomas W. Frazier^h ; Eric A. Youngstromⁱ ; Robert L. Findling^c ; ^j ; Mary L. Phillips^a ; ^k
• 关键词：BPSD ; bipolar spectrum disorder ; ADHD ; externalizing ; HC ; healthy controls ; FxC ; functional connectivity ; VLPFC ; ventrolateral prefrontal cortex ; ADHD ; Attention-Deficit Hyperactivity Disorder
• 刊名：Journal of Affective Disorders
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：208
• 期：Complete
• 页码：94-100
• 全文大小：361 K
• 卷排序：208

文摘

Amygdala FxC in response to emotion processing is abnormal in youth with BPSD. Amygdala-VLPFC FxC to all emotions is positive in BPSD but inverse in HC and ADHD. Amygdala-subgenual FxC to negative emotions is positive in BPSD but inverse in HC. VLPFC findings are specific to BPSD, and not found in youth with ADHD. Subgenual FxC also varies with depression and stimulant medication.