B-Alkyl Suzuki–Miyaura cross-coupling of tri-n-alkylboranes with arylbromides bearing acidic functions under mild non-aqueous conditions

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• 作者：Hui-Xia Sun ; Zhi-Hua Sun ; Bing Wang
• 刊名：Tetrahedron Letters
• 出版年：2009
• 出版时间：8 April 2009
• 年：2009
• 卷：50
• 期：14
• 页码：1596-1599
• 全文大小：1016 K

文摘

An efficient and chemoselective Pd-catalyzed B-alkyl Suzuki–Miyaura cross-coupling of tri-n-alkylboranes with arylbromides possessing acidic functions is described. This protocol features the relatively weak base Csb>2b>COb>3b> and mild non-aqueous conditions. Aldehydes, ketones, nitriles, and chloro substitution are all tolerated.