Effects of in vitro and in vivo avermectin exposure on alpha synuclein expression and proteasomal activity in pigeons

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Effects of in vitro and in vivo avermectin exposure on alpha synuclein expression and proteasomal activity in pigeons

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作者：Ming Li^a ; ^b ; Shuo Zhou^a ; Xian-Song Wang^a ; Ci Liu^a ; Shu Li^a ; ^{lishu@neau.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：AVM ; avermectin ; AVMs ; avermectins ; α-Syn ; alpha synuclein ; NAC ; non-amyloid-β-component ; AD ; Alzheimer disease ; NACP ; non-amyloid-β-component precursor ; PD ; Parkinson's disease ; MSA ; multiple system atrophy ; DLB ; Dementia with Lewy bodies ; UPP ; ubiquitin proteasome pathway ; E1 ; ubiquitin activating enzyme ; E2s ; ubiquitin transferase ; E3s ; ubiquitin ligase ; DUBs ; deubiquitinating enzymes ; DMSO ; dimethyl sulfoxide ; LC50 ; lethal concentration 50 ; qPCR ; quantitative real-time PCR ; PBS ; phosphate-b
刊名：Ecotoxicology and Environmental Safety
出版年：2017
出版时间：January 2017
年：2017
卷：135
期：Complete
页码：24-31
全文大小：1904 K

文摘

•: Avermectins (AVM) increased alpha synuclein in pigeon neurons.
•: Decreases in the proteasomal activity were observed in brain after AVM exposure.
•: The normal physiological function of proteasome could be inhibited by AVM.

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