Pathological α-synuclein exacerbates the progression of Parkinson’s disease through microglial activation

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• 作者：Qiu-Shuang Zhang^a ; Yang Heng^a ; Yu-He Yuan^a ; ^{yuanyuhe@imm.ac.cn} ; Nai-Hong Chen^a ; ^b ; ^{chennh@imm.ac.cn}
• 关键词：AKT ; protein kinase B ; AP-1 ; activator protein-1 ; BV-2 ; immortalized murine microglia cell line ; CD11b ; cluster of differentiation 11b ; CD36 ; cluster of differentiation 36 ; CD44 ; cluster of differentiation 44 ; CD68 ; cluster of differentiation 68 ; CNS ; central nervous system ; COX-2 ; cyclooxygenase-2 ; cPLA2 ; cytosolic phospholipase A2 ; EP2 ; prostaglandin E2 receptor subtype 2 ; ERK ; extracellular regulated kinases ; FcγRs ; Fc gamma receptors ; IKK ; IκB kinase ; IL-1β ; interleukin-1-β ; IL-6 ; interleuki
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：265
• 期：Complete
• 页码：30-37
• 全文大小：864 K
• 卷排序：265

文摘

Described the characters for α-synuclein induced microglial activation in detail. Summarized the pathways associated with α-synuclein induced microglial activation. Collected the receptors or signal modules in α-synuclein induced microglial activation. Discussed phagocytosis and migration in α-synuclein induced microglial activation.