Evolutionary sequence of cytogenetic aberrations during the oncogenesis of plasma cell disorders. Direct evidence at single cell level

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• 作者：Zs&#xf3 ; fia Nagy^a ; Bé ; la Kajtá ; r^a ; Pá ; l Já ; ks&#xf3 ; ^a ; Mariann Dá ; vid^b ; Szabolcs Kosztolá ; nyi^b ; Judit Hermesz^a ; Lá ; szl&#xf3 ; Kereskai^a ; Lá ; szl&#xf3 ; Pajor^a ; Doná ; t Alpá ; r^a ; ^{donat.alpar@kk.pte.hu"" rel=""nofollow}
• 关键词：Plasma cell disorder ; FISH ; Motorized microscopy ; Cytogenetic evolution ; Recurrent IGH translocation
• 刊名：Leukemia Research
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：35
• 期：8
• 页码：1114-1116
• 全文大小：246 K

文摘

Bone marrow specimens from 185 patients with plasma cell disorders (PCD) were investigated by fluorescence in situ hybridization (FISH) in order to determine the temporal sequence of cytogenetic aberrations. In 25 cases combined FISH analysis has also been performed at single cell level. Clonal evolution was observed in 16 % of cases. The Δ13 was preceded by t(4;14)(p16;q32) and t(14;16)(q32;q23) translocations. Deletion of p53 gene was a secondary aberration compared to Δ13 and t(11;14)(q13;q32) translocation. In 22 % of all cases with recurrent IGH translocation, this aberration was presented only in a subset of purified plasma cells questioning its initiating role.