Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem

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• 作者：Kajari Karmakar¹ ; ² ; ³ ; ⁴ ; Yuichi Narita¹ ; ³ ; ⁵ ; Jonathan Fadok¹ ; Sebastien Ducret¹ ; Alberto Loche¹ ; ² ; Taro Kitazawa¹ ; Christel Genoud¹ ; Thomas Di Meglio¹ ; ⁶ ; Raphael Thierry¹ ; Joao Bacelo¹ ; ⁷ ; Andreas Lü ; thi¹ ; ² ; Filippo M. Rijli¹ ; ² ; ⁸ ; ^{filippo.rijli@fmi.ch}
• 关键词：tonotopic map formation ; homeodomain transcription factors ; brainstem auditory nuclei development ; glutamatergic cochlear neurons ; bushy cells ; endbulb of held ; sound frequency discrimination ; auditory circuit refinement
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：185-197
• 全文大小：4943 K
• 卷排序：18

文摘

Hox2 genes are expressed in glutamatergic cells of the anteroventral cochlear nucleus Hox2 deletion results in impaired refinement of endbulb of Held presynaptic input Hox2 deletion results in impaired tonotopic precision of sound transmission Hox2 mutant mice fail to discriminate close sound frequencies in behavioral tests