Coordinated Acetylcholine Release in Prefrontal Cortex and Hippocampus Is Associated with Arousal and Reward on Distinct Timescales

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• 作者：Leonor M. Teles-Grilo Ruivo¹ ; ² ; ⁴ ; Keeley L. Baker³ ; ⁴ ; Michael W. Conway¹ ; Peter J. Kinsley¹ ; Gary Gilmour¹ ; Keith G. Phillips¹ ; John T.R. Isaac¹ ; John P. Lowry³ ; ^{john.lowry@nuim.ie} ; Jack R. Mellor² ; ⁵ ; ^{jack.mellor@bristol.ac.uk}
• 关键词：acetylcholine ; hippocampus ; prefrontal cortex ; biosensor
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：18
• 期：4
• 页码：905-917
• 全文大小：3337 K
• 卷排序：18

文摘

Acetylcholine release is coordinated in prefrontal cortex and hippocampus Tonic and phasic release are maximal during training on a cognitive task Tonic acetylcholine release during REM sleep predicts subsequent wakefulness Phasic acetylcholine release is preferentially associated with reward