Effects of chronic restraint-induced stress on radiation-induced chromosomal aberrations in mouse splenocytes

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• 作者：Takanori Katsube^a ; ^{katsube.takanori@qst.go.jp} ; Bing Wang^a ; ^{wang.bing@qst.go.jp} ; Kaoru Tanaka^a ; ^{tanaka.kaoru@qst.go.jp} ; Yasuharu Ninomiya^a ; ^{ninomiya.yasuharu@qst.go.jp} ; Guillaume Varè ; s^b ; ^{guillaume.vares@oist.jp} ; Taiki Kawagoshi^a ; ^{kawagoshi.taiki@qst.go.jp} ; Naoko Shiomi^a ; ^{shiomi.naoko@qst.go.jp} ; Yoshihisa Kubota^a ; ^{kubota.yoshihisa@qst.go.jp} ; Qiang Liu^c ; ^{liuqiang@irm-cams.ac.cn} ; Akinori Morita^d ; ^{morita@tokushima-u.ac.jp} ; Tetsuo Nakajima^a ; ^{nakajima.tetsuo@qst.go.jp} ; Mitsuru Nenoi^a ; ^{nenoi.mitsuru@qst.go.jp}
• 关键词：Chronic restraint-induced psychological stress ; Total body irradiation ; Fluorescence in situ hybridization (FISH) ; Mouse restraint model
• 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：813
• 期：Complete
• 页码：18-26
• 全文大小：1075 K
• 卷排序：813

文摘

Combined effects of psychological stress and X-rays on wild type mice were analysed. Either psychological stress or X-rays reduced the number of splenocytes. Psychological stress alone did not induce chromosomal aberrations in splenocytes. Psychological stress did not appear to synergize with the clastogenicity of X-rays. Psychological stress may not synergize with radiocarcinogenesis in wild type mice.