Molecular cloning, characterization and expression analysis of TGF-β and receptor genes in the woodchuck model

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Molecular cloning, characterization and expression analysis of TGF-β and receptor genes in the woodchuck model

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作者：Lu Wang^a ; Junzhong Wang^a ; Yana Liu^a ; Baoju Wang^a ; Shangqing Yang^a ; Qing Yu^a ; Michael Roggendorf^b ; Mengji Lu^b ; Jia Liu^a ; ¹ ; ^{jialiu77@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Dongliang Yang^a ; ¹ ; ^{dlyang@hust.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：TGF-β ; transforming growth factor beta ; TGFBR ; TGF-β receptor ; WHV ; woodchuck hepatitis virus ; HBV ; hepatitis B virus ; CDS ; coding sequence ; HCC ; hepatocellular carcinoma ; ORF ; open reading frame ; pI ; isoelectric point ; ConA ; concanavalin A ; PBMC ; peripheral blood mononuclear cell ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; RPL4 ; ribosomal protein L4 ; CypA ; cyclophilin A ; TBP ; TATA binding protein
刊名：Gene
出版年：2016
出版时间：20 December 2016
年：2016
卷：595
期：1
页码：1-8
全文大小：1451 K

文摘

•: The cDNA sequences of woodchuck TGFBR1, TGFBR2 and TGF-β2 were cloned, sequenced and characterized for the first time.
•: The expression patterns of TGF-β family members were examined in naïve woodchuck and in woodchucks with WHV infection.
•: An antibody that can be used for woodchuck TGFBR1 staining was identified.

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