Global gene expression profile of peripheral blood mononuclear cells challenged with Theileria annulata in crossbred and indigenous cattle

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• 作者：Amod Kumar^a ; Gyanendra Kumar Gaur^a ; ^{gyanendrakg@gmail.com} ; Ravi Kumar Gandham^c ; ^{gandham71@gmail.com} ; Manjit Panigrahi^a ; Shrikant Ghosh^b ; B.C. Saravanan^b ; Bharat Bhushan^a ; Ashok Kumar Tiwari^c ; Sourabh Sulabh^a ; Bhuvana Priya^d ; Muhasin Asaf V.N^a ; Jay Prakash Gupta^a ; Sajad Ahmad Wani^c ; Amit Ranjan Sahu^c ; Aditya Prasad Sahoo^c
• 关键词：Theileria annulata ; Crossbred ; Tharparkar cattle ; Microarray
• 刊名：Infection, Genetics and Evolution
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：47
• 期：Complete
• 页码：9-18
• 全文大小：1555 K
• 卷排序：47

文摘

PBMC are challenged with Theileria sporozoites in vitro. Cross-bred cattle showed 1082 differentially expressed genes (DEGs) (597 down-regulated, 485 up-regulated). Tharparkar cattle showed 875 DEGs (451 downregulated, 424 up-regulated). GO analysis of DEGs confirmed their involvement in various important pathways involved in Theileria infection. Protein-protein interaction network analysis gives differentially expressed highly connected molecules.