The long non-coding RNA 91H increases aggressive phenotype of breast cancer cells and up-regulates H19/IGF2 expression through epigenetic modifications

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• 作者：Constance Vennin^a ; ^b ; Nathalie Spruyt^c ; Yves-Marie Robin^a ; ^d ; Thierry Chassat^e ; Xuefen Le Bourhis^a ; ^b ; ¹ ; Eric Adriaenssens^a ; ^b ; ¹ ; ^{eric.adriaenssens@univ-lille1.fr} ;
• 关键词：H19 antisense ; Long non-coding RNA ; Breast tumorigenesis ; Genomic imprinting
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：198-206
• 全文大小：1379 K
• 卷排序：385

文摘

91H RNA have an oncogenic role in breast cancer. 91H RNA regulates both H19 and IGF2 expression. 91H RNA prevents epigenetic modifications on maternal allele. 91H RNA allows the maintenance of genomic imprinting.