Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities

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Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities

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作者：Eugene L. Piatnitski Chekler¹ ; Jessica A. Pellegrino² ; Thomas A. Lanz³ ; R. Aldrin Denny¹ ; Andrew C. Flick⁴ ; Jotham Coe⁴ ; Jonathan Langille⁴ ; Arindrajit Basak⁴ ; Shenping Liu⁵ ; Ingrid A. Stock⁶ ; Parag Sahasrabudhe⁵ ; Paul D. Bonin⁶ ; Kevin Lee⁷ ; Mathew T. Pletcher⁷ ; Lyn H. Jones¹ ; ^{lyn.jones@pfizer.com" class="auth_mail" title="E-mail the corresponding author}
刊名：Chemistry & Biology
出版年：2015
出版时间：17 December 2015
年：2015
卷：22
期：12
页码：1588-1596
全文大小：2297 K

文摘

•: PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain
•: PF-CBP1 modulates key inflammatory genes in primary macrophages
•: PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease

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