Interleukin-35 attenuates collagen-induced arthritis through suppression of vascular endothelial growth factor and its receptors

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Interleukin-35 attenuates collagen-induced arthritis through suppression of vascular endothelial growth factor and its receptors

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作者：Suqin Wu^a ; ^b ; Yunxia Li^a ; Yuxuan Li^a ; Lutian Yao^c ; Tiantian Lin^a ; Shenyi Jiang^a ; Hui Shen^a ; Liping Xia^a ; Jing Lu^a ; ^{lujingtan@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Collagen-induced arthritis ; Interleukin-35 ; Vascular endothelial growth factor ; Rheumatoid arthritis
刊名：International Immunopharmacology
出版年：2016
出版时间：May 2016
年：2016
卷：34
期：Complete
页码：71-77
全文大小：1360 K

文摘

•: The novel cytokine IL-35 could attenuate the pathologic change of CIA mouse model.
•: IL-35 could inhibit VEGF and its receptors in the synovial tissue of CIA mouse model.
•: Anti-angiogenesis function of IL-35 indicates potentiality in neovascular diseases.

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