Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

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作者：Kumar Sanjiv¹ ; Anna Hagenkort¹ ; José ; Manuel Calderó ; n-Montañ ; o¹ ; Tobias Koolmeister¹ ; Philip M. Reaper² ; Oliver Mortusewicz¹ ; Sylvain A. Jacques¹ ; Raoul V. Kuiper³ ; Niklas Schultz¹ ; Martin Scobie¹ ; Peter A. Charlton² ; John R. Pollard² ; Ulrika Warpman Berglund¹ ; Mikael Altun¹ ; Thomas Helleday¹ ; ^{thomas.helleday@scilifelab.se" class="auth_mail" title="E-mail the corresponding author}
关键词：ATR ; CHK1 ; synthetic lethality ; cancer ; DNA damage ; replication stress
刊名：Cell Reports
出版年：2016
出版时间：12 January 2016
年：2016
卷：14
期：2
页码：298-309
全文大小：4813 K

文摘

•: Synthetic lethality within the same pathway is via the induction of replication catastrophe
•: New origin firing and replication stress induced by CHK1 inhibitor reliance on ATR
•: ATR and CHK1 inhibitor combination results in cancer-specific cytotoxicity
•: ATR and CHK1 inhibitor combination could be used broadly across cancer indications

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