High glucose down-regulates microRNA-181a-5p to increase pro-fibrotic gene expression by targeting early growth response factor 1 in HK-2 cells

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• 作者：Ping Xu^a ; ^b ; ¹ ; ^{dudu20101202@163.com} ; Mei-ping Guan^a ; ¹ ; Jian-gang Bi^c ; Dan Wang^a ; Zong-ji Zheng^a ; Yao-ming Xue^a ; ^{xymbright@126.com}
• 关键词：COL I ; collagen I ; DKD ; diabetic kidney disease ; DMEM ; Dulbecco's modified Eagle's medium ; DN ; diabetic nephropathy ; ECM ; extracellular matrix ; Egr1 ; early growth response factor 1 ; ESRD ; end-stage renal disease ; FBS ; fetal bovine serum ; FN ; fibronectin ; HEK293 ; human embryonic kidney 293 cell line ; HG ; high glucose ; HK-2 ; human proximal tubule cell line ; LETO ; Long&ndash ; Evans&ndash ; Tokushima&ndash ; Otsuka ; miR-181a-5p ; microRNA-181a-5p ; NG ; normal glucose ; OLETF ; Otsuka&ndash ; Long&ndash ; Evans&n
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：Complete
• 页码：96-104
• 全文大小：1613 K
• 卷排序：31

文摘

Egr1 contributes to the development of renal tubulointerstitial fibrosis (TIF) in diabetic nephropathy (DN). Identification of miR-181a-5p as an upstream regulator of Egr1 in DN miR-181a-5p/Egr1 pathway may promote the progression of TIF in DN.