Carbamazepine enhances brain production of kynurenic acid in vitro

详细信息    查看全文

• 作者：Kocki ; Tomasz ; Kocki ; Janusz ; Wielosz ; Marian ; Turski ; Waldemar A. ; Urbanska ; Ewa M.
• 关键词：Kynurenic acid ; Carbamazepine
• 刊名：European Journal of Pharmacology
• 出版年：2004
• 出版时间：September 13, 2004
• 年：2004
• 卷：498
• 期：1-3
• 页码：325-326
• 全文大小：116 K

文摘

Disturbed formation of kynurenic acid, an endogenous antagonist of glutamate ionotropic receptors, might contribute to the pathogenesis of seizures. Here, the effect of anticonvulsant drug, carbamazepine on the production of kynurenic acid was studied. Carbamazepine (0.5aaa3 mM) enhanced kynurenic acid synthesis in rat cortical slices and also increased the activity of kynurenine aminotransferase (KAT) I at 0.1aaa3.0 mM concentration. Thus, anticonvulsant drugs, such as carbamazepine, might act partially via stimulation of kynurenic acid production.