High levels of plasma cortisol and impaired hypoosmoregulation in a mutant medaka deficient in P450c17I

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High levels of plasma cortisol and impaired hypoosmoregulation in a mutant medaka deficient in P450c17I

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作者：Hideya Takahashi^a ; ^b ; Tadashi Sato^a ; Toshitaka Ikeuchi^c ; Kazuhiro Saito^b ; Mitsuru Sakaizumi^a ; Tatsuya Sakamoto^b ; ^{ryu@uml.okayama-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
关键词：Medaka ; Cortisol ; Intestine ; Osmoregulation ; Glucocorticoid receptor ; Mineralocorticoid receptor
刊名：Molecular and Cellular Endocrinology
出版年：2016
出版时间：15 July 2016
年：2016
卷：430
期：Complete
页码：25-32
全文大小：916 K

文摘

•: Plasma cortisol in P450c17I-deficient (scl) medaka is at a high physiological level.
•: After seawater transfer, scl is more dehydrated than wild type medaka.
•: Intestinal GRs and Na/K/2Cl cotransporter are not induced in scl after the transfer.
•: scl may provide a model to study the roles of glucocorticoids and sex steroids.

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