Transcriptional response to mitochondrial protease IMMP2L knockdown in human primary astrocytes

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• 作者：Akira Gokoolparsadh^a ; Zhiming Fang^a ; Nady Braidy^a ; Peijie Lin^a ; Christopher J. Pardy^a ; Valsamma Eapen^b ; Raymond Clarke^c ; Irina Voineagu^a ; ^{i.voineagu@unsw.edu.au}
• 关键词：Transcription ; Mitochondria ; IMMP2L ; Tourette syndrome ; Retrograde signaling ; Human primary astrocytes
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1252-1258
• 全文大小：1307 K
• 卷排序：482

文摘

Mutations in mitochondrial peptidase, IMMP2L are associated with Tourette syndrome. The downstream effects of IMMP2L dysfunction in the human brain remain unclear. IMMP2L transcription requires Topoisomerase I in human primary astrocytes. IMMP2L knockdown leads to dysregulation of genes involved in central nervous system development. The transcriptional response to IMMP2L KD partially overlaps mitochondrial complex III inhibition.