Effect of antidepressants on circadian rhythms in fish: Insights and implications regarding the design of behavioural toxicity tests.

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• 作者：Steven D. Melvin ; ^{s.melvin@griffith.edu.au} ; ^{smelvin18@gmail.com}
• 关键词：Antidepressants ; Pharmaceuticals ; Fish ; Behaviour ; Circadian rhythm ; Diurnal activity ; Mixture ; Multispecies Freshwater Biomonitor®
• 刊名：Aquatic Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：20-30
• 全文大小：707 K
• 卷排序：182

文摘

Antidepressants pose risks to aquatic animals and may affect fish behaviour. Toxicity information is needed to document biologically relevant endpoints. Circadian rhythms are under neuroendocrine control but have not been studied. Diurnal activity patterns were studied in fish exposed to SSRI and SNRI antidepressants. A mixture of fluoxetine, sertraline and venlafaxine upset these rhythms at 1 and 100 μg/L.