Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

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Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

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作者：Kelly L. Warfield^a ; ¹ ; ^{warfieldk@ebsi.com" class="auth_mail" title="E-mail the corresponding author} ; Emily M. Plummer^b ; ¹ ; ^{Emily.plummer@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Andrew C. Sayce^c ; ¹ ; ^{andrew.sayce@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Dominic S. Alonzi^c ; ^{dominic.alonzi@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; William Tang^b ; ^{wtang@lji.org" class="auth_mail" title="E-mail the corresponding author} ; Beatrice E. Tyrrell^c ; ^{beatrice.tyrrell@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Michelle L. Hill^c ; ^{michelle.hill@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Alessandro T. Caputo^c ; ^{alessandro.caputo@stx.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Sarah S. Killingbeck^d ; ^{sskillingbeck@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author} ; P. Robert Beatty^d ; ^{prbeatty@berkeley.edu" class="auth_mail" title="E-mail the corresponding author} ; Eva Harris^d ; ^{eharris@berkeley.edu" class="auth_mail" title="E-mail the corresponding author} ; Ren Iwaki^e ; ^{r-iwaki@fujichemical.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Kyoko Kinami^e ; ^{s1160215@ems.u-toyama.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Daisuke Ide^e ; ^{s1260204@ems.u-toyama.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; J.L. Kiappes^c ; ^{john.kiappes@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Atsushi Kato^e ; ^{kato@med.u-toyama.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Michael D. Buck^b ; ^{mdsbuck@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kevin King^b ; ^{kevindalesamuelking@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; William Eddy^b ; ^{william.e.eddy@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mansoora Khaliq^a ; ^{khlaliqm@ebsi.com" class="auth_mail" title="E-mail the corresponding author} ; Aruna Sampath^a ; ^{sampatha1@ebsi.com" class="auth_mail" title="E-mail the corresponding author} ; Anthony M. Treston^a ; ^{trestona@ebsi.com" class="auth_mail" title="E-mail the corresponding author} ; Raymond A. Dwek^c ; ^{raymond.dwek@exeter.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Sven G. Enterlein^f ; ^{sven@integratedbiotherapeutics.com" class="auth_mail" title="E-mail the corresponding author} ; Joanna L. Miller^c ; ^{joanna.miller@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Nicole Zitzmann^c ; ^{nicole.zitzmann@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Urban Ramstedt^g ; ^{urban_ramstedt@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Sujan Shresta^b ; ^{sujan@lji.org" class="auth_mail" title="E-mail the corresponding author}
关键词：Iminosugar ; UV-4B ; Dengue ; Antibody-dependent enhancement ; Antiviral ; Glucosidase
刊名：Antiviral Research
出版年：2016
出版时间：May 2016
年：2016
卷：129
期：Complete
页码：93-98
全文大小：1014 K

文摘

class="label">•: The iminosugar UV-4B has in vitro activity against all 4 dengue virus serotypes.
class="label">•: Inhibition of ER α-glucosidases is responsible for UV-4B activity against dengue.
class="label">•: In vivo efficacy studies inform clinical trial design for UV-4B treatment of dengue.