Cellular permeation of large molecules mediated by TRPM8 channels

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• 作者：Daniel D. McCoy^a ; ^b ; ^{daniel.david.mccoy@gmail.com} ; Radhika Palkar^a ; ^c ; ^{rpalkar@usc.edu} ; Yuening Yang^a ; ^b ; ^{yueningy@usc.edu} ; Serra Ongun^a ; ^b ; ^{ongun@usc.edu} ; David D. McKemy^a ; ^b ; ^c ; ^{mckemy@usc.edu}
• 关键词：TRPM8 ; Channel ; Permeation ; Qx-314 ; Cold ; Pain
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：59-67
• 全文大小：2979 K
• 卷排序：639

文摘

Large molecules permeate heterologous cells and sensory neurons expressing TRPM8 ion channels. Molecule permeation induced by the TRPM8 agonist WS-12 is channel-dependent. The cell-impermeant lidocaine derivative QX-314 blocks voltage-gated Na+-channels in cells expressing activated TRPM8. Along with prior analysis of TRPV1 and TRPA1 channels, these data show that pain and somatosensory TRP channels can permeate large molecules.