2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice

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2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice

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作者：Robert W. Moore^a ; ^b ; ¹ ; ^{robert.moore@wisc.edu" class="auth_mail" title="E-mail the corresponding author} ; Wayne A. Fritz^a ; ^b ; ¹ ; ² ; ^{Wayne.Fritz@covance.com" class="auth_mail" title="E-mail the corresponding author} ; Andrew J. Schneider^a ; ^{ajschnei@wisc.edu" class="auth_mail" title="E-mail the corresponding author} ; Tien-Min Lin^a ; ^{tlin1@facstaff.wisc.edu" class="auth_mail" title="E-mail the corresponding author} ; Amanda M. Branam^a ; ^b ; ³ ; ^{bran2117@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Stephen Safe^c ; ^{SSAFE@cvm.tamu.edu" class="auth_mail" title="E-mail the corresponding author} ; Richard E. Peterson^a ; ^b ; ^{richard.peterson@wisc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：AHT ; atypical hyperplasia of Tag ; AHR ; aryl hydrocarbon receptor ; DIM ; 3 ; 3&prime ; -diindolylmethane ; I3C ; indole-3-carbinol ; IUL ; in utero and lactational ; NEPC ; neuroendocrine prostate carcinoma ; SAHRM ; selective AHR modulator ; Tag ; simian virus 40 large T and small t antigens ; TCDD ; 2 ; 3 ; 7 ; 8-tetrachlorodibenzo-p-dioxin ; TRAMP ; Transgenic Adenocarcinoma of the Mouse Prostate
刊名：Toxicology and Applied Pharmacology
出版年：2016
出版时间：15 August 2016
年：2016
卷：305
期：Complete
页码：242-249
全文大小：1244 K

文摘

•: TRAMP mice model aggressive neuroendocrine prostate carcinomas in men
•: In utero/lactational TCDD exposure raised prostate cancer incidence in TRAMP mice.
•: TCDD treatment in adulthood lowered prostate cancer incidence in TRAMP mice.
•: No significant protection was seen in TRAMP mice given I3C or DIM in adulthood.
•: This is the first report that TCDD alters prostate cancer incidence in lab animals.

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