Relationship between RSUME and HIF-1α/VEGF-A with invasion of pituitary adenoma

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• 作者：Wei He¹ ; Ling Huang¹ ; Xiaoli Shen ; ¹ ; ^{shenxldoc@126.com} ; Yanlin Yang ; Dapeng Wang ; Yue Yang ; Xingen Zhu
• 关键词：RSUME ; RWD containing sumoylation enhancer ; SUMO-1 ; small ubiquitin related modifiers-1 ; HIF-1α ; hypoxia-inducible factor-1α ; VEGF-A ; vascular endothelial growth factor A ; siRNA ; small interfering RNA ; IOD ; integral optical density ; qRT-PCR ; real-time quantitative reverse transcriptase polymerase chain reaction ; DEPC ; diethyl pyrocarbonate ; UBB ; ubiquitin B ; CoCl2 ; cobalt chloride ; PBS ; phosphate buffer saline ; DAB ; 3 ; 3&prime ; -diaminobenzidine
• 刊名：Gene
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：603
• 期：Complete
• 页码：54-60
• 全文大小：1039 K
• 卷排序：603

文摘

RSUME enhance sumoylation for pituitary adenoma invasion is proposed. The mechanism relies on RSUME stabilizing HIF-1α through sumoylation. RSUME silencing can inhibit the invasion of pituitary adenoma cells.