Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond

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• 作者：Carlos H. Villa^a ; ^{carlos.villa@uphs.upenn.edu} ; Douglas B. Cines^b ; Don L. Siegel^b ; Vladimir Muzykantov^b
• 关键词：Red blood cells ; Drug delivery ; Pharmacokinetics ; Biocompatibility ; Immunogenicity
• 刊名：Transfusion Medicine Reviews
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：26-35
• 全文大小：812 K
• 卷排序：31

文摘

Red blood cells (RBCs) are promising carriers for biotherapeutics to enhance their pharmacokinetics and control their site and mechanism of action. RBC drug carriers include those loaded internally or externally and may be prepared ex vivo or in vivo from allogeneic or autologous units. Surface coupling onto membrane antigens offers a biocompatible, flexible platform for loading of drugs. The optimal epitopes for coupling onto RBCs remain to be definitively characterized. Drug loading onto RBCs may alter immune responses, including potential induction of tolerance.