Lipid topogenesis — 35 </ce:hsp>years on

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Lipid topogenesis — 35 years on

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作者：Neha Chauhan^a ; ¹ ; Luce Farine^b ; ¹ ; Kalpana Pandey^a ; ¹ ; Anant K. Menon^a ; ^{akm2003@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author} ; Peter Bü ; tikofer^b ; ^{peter.buetikofer@ibmm.unibe.ch" class="auth_mail" title="E-mail the corresponding author}
关键词：C/EPT ; choline/ethanolamine phosphotransferase ; CDP ; cytidine diphosphate ; CDS ; CDP-DAG synthase ; CL ; cardiolipin ; DGAT ; diacylglycerol acyltransferase ; DIPPS ; di-myo-inositol-1 ; 3&prime ; -phosphate-1&prime ; -phosphate synthase ; GPCR ; G protein-coupled receptor ; GPI ; glycosylphosphatidylinositol ; IPCT ; L-myo-inositol-1-phosphate cytidylyltransferase ; PA ; phosphatidic acid ; PC ; phosphatidylcholine ; PE ; phosphatidylethanolamine ; PG ; phosphatidylglycerol ; PI ; phosphatidylinositol ; PIPS ; phosphatidylin
刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
出版年：2016
出版时间：August 2016
年：2016
卷：1861
期：8
页码：757-766
全文大小：1253 K

文摘

•: Early events of lipid topogenesis: synthesis, integration and translocation
•: Scramblases are required for distribution of lipids to both faces of the ER membrane.
•: Crystal structures of lipid biosynthetic enzymes
•: ER and mitochondria have distinct CDS enzymes for cytoplasmic synthesis of CDP-DAG.
•: Topology of PI synthesis differs between Saccharomycescerevisiae and Trypanosoma brucei.

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