Transmembrane tumor necrosis factor-α promotes the recruitment of MDSCs to tumor tissue by upregulating CXCR4 expression via TNFR2

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• 作者：Hongping Ba^a ; ^{bhpsky@163.com} ; Baihua Li^a ; ^b ; ^{libaihua1986@126.com} ; Xiaoyan Li^a ; ^{lxyfly2003@163.com} ; Cheng Li^a ; ^{licheng.0419@163.com} ; Anlin Feng^a ; ^{543683753@qq.com} ; Yazhen Zhu^a ; ^{zhuyz0918@163.com} ; Jing Wang^a ; ^{wangjhxh@163.com} ; Zhuoya Li^a ; ^{zhuoyali@mails.tjmu.edu.cn} ; Bingjiao Yin^a ; ^{bingjiao.yin@hust.edu.cn}
• 关键词：Myeloid-derived suppressor cells (MDSC) ; Tumor ; Chemotaxis ; CXCR4 ; Transmembrane tumor necrosis factor-α ; TNF receptor
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：143-152
• 全文大小：1471 K
• 卷排序：44

文摘

TNFR deficiency decreases MDSC accumulation in blood, spleen and tumor tissues. TNFR deficiency reduces CXCR4 expression in MDSCs and thus impaired their chemotaxis. tmTNF-α induces CXCR4 expression in MDSCs via TNFR2 by NF-κB and p38 pathways.