Modeling structural transitions from the periplasmic-open state of lactose permease and interpretations of spin label experiments

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Modeling structural transitions from the periplasmic-open state of lactose permease and interpretations of spin label experiments

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作者：Xiaohong Zhuang^a ; Jeffery B. Klauda^a ; ^b ; ^{jbklauda@umd.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Molecular simulation ; Transmembrane protein ; DEER ; MDDS
刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
出版年：2016
出版时间：July 2016
年：2016
卷：1858
期：7
页码：1541-1552
全文大小：1783 K

文摘

•: Lactose permease (LacY) is periplasmic open when E269 is protonated
•: MDDS simulations demonstrate that spin label orientations can affect interpretation of DEER experiments
•: Placement of spin label can result in restricted conformational space and differs between pairs in LacY
•: Careful interpretation of DEER may require the computational techniques to aid in spin label distance assignments

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