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Background
Sk
in cancer is the most common malignancy to arise after organ
transplantation
in Cauc
asians, but limited data are available on its
incidence
in Asian
transplant recipients.
Objective
We sought to assess the incidence of skin cancer after organ transplantation in a Korean cohort.
Methods
A cohort study was conducted to determine the incidence and risk factors for skin cancers among kidney, liver, heart, or pancreas transplant recipients, treated at the Asan Medical Center in Seoul, Korea.
Results
The cumulative incidences of skin cancer were 0.70% at 5聽years, 1.66% at 10聽years, and 2.31% at 15聽years. For all skin cancers, squamous cell carcinoma, basal cell carcinoma, and Kaposi sarcoma, the standardized incidence ratios between the recipients and the Korean general population were 30.9 (95% confidence interval, 12.4-63.6), 61.9 (12.8-180.8), 11.9 (0.3-66.1), and 565.2 (68.4-2041.6) after the end of the fifth posttransplantation year, respectively.
Limitations
We cannot exclude the possibility of both the underestimation because of potential missing cases and the overestimation because of the ascertainment bias.
Conclusion
The incidence of posttransplantation skin cancer is very low in Korean patients. However, the risk of skin cancer in organ transplant recipients may be considerably higher than that in the Korean general population.
