Effects of pretransplant sarcopenia and sequential changes in sarcopenic parameters after living donor liver transplantation

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• 作者：Toshimi Kaido ; M.D. ; Ph.D.^a ; ^{kaido@kuhp.kyoto-u.ac.jp} ; Yumiko Tamai ; M.D.^b ; Yuhei Hamaguchi ; M.D.^a ; Shinya Okumura ; M.D. ; Ph.D.^a ; Atsushi Kobayashi ; M.D.^a ; Hisaya Shirai ; M.D.^a ; Shintaro Yagi ; M.D. ; Ph.D.^a ; Naoko Kamo ; M.D. ; Ph.D.^a ; Ahmed Hammad ; M.D.^a ; ^c ; Nobuya Inagaki ; M.D. ; Ph.D.^b ; ^d ; Shinji Uemoto ; M.D. ; Ph.D.^a
• 关键词：Sarcopenia ; Liver transplantation ; Skeletal muscle mass ; Grip strength ; Nutrition
• 刊名：Nutrition
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：Complete
• 页码：195-198
• 全文大小：415 K
• 卷排序：33

文摘

Sarcopenia is characterized by muscle mass depletion and decrease in muscle power or physical activity. We prospectively investigated the effects of pretransplant sarcopenia, defined as low skeletal muscle mass (SMM), using a multifrequency body composition analyzer and low grip strength on survival and examined sequential changes in sarcopenic parameters after living donor liver transplantation (LDLT). Overall survival rates were significantly lower in patients with sarcopenia (n = 10) than those without sarcopenia (n = 62; P < 0.001). Grip strength recovers earlier compared with SMM after LDLT.