Hitchhiking: A Non-Canonical Mode of Microtubule-Based Transport

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• 作者：John Salogiannis¹ ; ² ; ³ ; Samara L. Reck-Peterson¹ ; ² ; ³ ; ^{sreckpeterson@ucsd.edu}
• 关键词：hitchhiking ; endosome ; microtubule ; dynein ; kinesin ; peroxisome
• 刊名：Trends in Cell Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：27
• 期：2
• 页码：141-150
• 全文大小：1687 K
• 卷排序：27

文摘

The long-range movement of organelles, vesicles, and macromolecular complexes by microtubule-based transport is crucial for cell growth and survival. The canonical view of intracellular transport is that each cargo directly recruits molecular motors via cargo-specific adaptor molecules. Recently, a new paradigm called ‘hitchhiking’ has emerged: some cargos can achieve motility by interacting with other cargos that have already recruited molecular motors. In this way, cargos are co-transported together and their movements are directly coupled. Cargo hitchhiking was discovered in fungi. However, the observation that organelle dynamics are coupled in mammalian cells suggests that this paradigm may be evolutionarily conserved. We review here the data for hitchhiking and discuss the biological significance of this non-canonical mode of microtubule-based transport.