Nanosecond pulsed electric field induced dose dependent phosphatidylinositol-_4,5-bisphosphate signaling and intracellular electro-sensitization

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• 作者：Gleb P. Tolstykh^a ; ^{gleb.tolstykh.ctr@us.af.mil} ; Melissa Tarango^a ; Caleb C. Roth^b ; Bennett L. Ibey^b
• 关键词：Nanosecond electric pulses ; PIP2 depletion ; Diacylglycerol ; Inositol-1 ; 4 ; 5-trisphosphate ; Nanoporation ; Membrane
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1859
• 期：3
• 页码：438-445
• 全文大小：1462 K
• 卷排序：1859

文摘

nsEPs exposure caused PIP2 hydrolysis and initiate intracellular signaling. PIP2 depletion follows plasma membrane nanoporation and modulates ion channels. nsEPs-induced intracellular PIP2 signaling is electric field dose-dependent. nsEPs dependent IP3 production is critical for electro-sensitization.