Familial partial lipodystrophy (FPL) is a rare genetic disorder.

FPL is characterized by selective lack of subcutaneous fat.

FPL is associated with insulin resistant diabetes.

Heterozygous mutations in the lamin A/C (LMNA) gene cause FPL2.

We describe a novel heterozygous missense LMNA mutation, D47N, in exon 1.