The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes

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• 作者：Kathryn M. Thrailkill ; MD^a ; ^b ; ^{kathryn.thrailkill@uky.edu} ; Jeffry S. Nyman ; PhD^c ; ^d ; ^f ; R. Clay Bunn ; PhD^a ; ^b ; Sasidhar Uppuganti ; MS^c ; ^d ; ^f ; Katherine L. Thompson ; PhD^e ; Charles K. Lumpkin Jr ; PhD^g ; Evangelia Kalaitzoglou ; MD^a ; ^b ; John L. Fowlkes ; MD^a ; ^b
• 关键词：Bone microarchitecture ; Cortical bone ; Trabecular bone ; Glycosuria ; Hypercalciuria ; Canagliflozin ; Dapagliflozin
• 刊名：Bone
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：Complete
• 页码：141-151
• 全文大小：993 K
• 卷排序：94

文摘

Deficits in appendicular and axial bone microarchitecture and strength are consistently observed in long-term hypoinsulinemic diabetes Normalization of glycemic control, via SGLT2I + insulin co-therapy, prevents diabetic bone disease in a mouse model of T1D Glycemic status is predictive of bone phenotype SGLT2-Inhibitor therapy alone may impart secondary effects on bone turnover. Monitoring the effects of SGLT2Is on skeletal outcomes remains relevant