Label-free detection of 3-nitro-l-tyrosine with nickel-doped graphene localized surface plasmon resonance biosensor

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Label-free detection of 3-nitro-l-tyrosine with nickel-doped graphene localized surface plasmon resonance biosensor

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作者：Siu Pang Ng^a ; Guangyu Qiu^a ; Ning Ding^a ; ^b ; Xiaoqing Lu^c ; Chi-Man Lawrence Wu^a ; ^b ; ^{lawrence.wu@cityu.edu.hk" class="auth_mail" title="E-mail the corresponding author}
关键词：Label-free biosensor ; 3-Nitro-l-tyrosine ; Nickel-doped graphene ; Localized surface plasmon resonance ; Differential phase detection
刊名：Biosensors and Bioelectronics
出版年：2017
出版时间：15 March 2017
年：2017
卷：89
期：part_P1
页码：468-476
全文大小：3339 K

文摘

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Label-free detection of 3-nitro-lass="smallcaps">l-tyrosine (3-NT) in PBS and human serum.

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Nickel-doped-graphene (NDG) receptor with high binding specificity to 3-NT.

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Phase detecting localized surface plasmon resonance (LSPR) interferometric biosensor.

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Detection limit of 3-NT in PBS was found to be 0.13 pg/ml.

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The linear dynamic range covers 0.5 pg/ml to 1 ng/ml, i.e. four orders of magnitude.

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A direct chemisorption immunoassay for early diagnostic of 3-NT related disorders in rapid, economical, and non-invasive manners.

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