Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation

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Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation

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作者：Gonç ; alo Garcia^a ; ^b ; Sara Nanni^b ; ^c ; Inê ; s Figueira^b ; Ines Ivanov^b ; ^c ; Gordon J. McDougall^d ; Derek Stewart^d ; ^e ; Ricardo B. Ferreira^g ; Paula Pinto^b ; ^f ; Rui F.M. Silva^c ; ^h ; Dora Brites^c ; ^h ; ^{dbrites@ff.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author} ; Clá ; udia N. Santos^a ; ^b ; ^{csantos@itqb.unl.pt" class="auth_mail" title="E-mail the corresponding author}
关键词：Polyphenols ; Raspberry ; Bioaccessibility ; Oxidative stress ; Neuroprotective mechanisms ; Neuroinflammation
刊名：Food Chemistry
出版年：2017
出版时间：15 January 2017
年：2017
卷：215
期：Complete
页码：274-283
全文大小：1031 K

文摘

•: Raspberry digested metabolites protect neurons and microglia towards H₂O₂ and LPS insults.
•: Neuroprotection is independent of intracellular ROS scavenging.
•: Microglial M1 activation by LPS is attenuated by raspberry metabolites.

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