Connecting the pathology of posttraumatic stress and substance use disorders: Monoamines and neuropeptides

详细信息    查看全文

• 作者：Nicole M. Enman ; Yong Zhang ; Ellen M. Unterwald
• 关键词：Posttraumatic stress disorder ; Substance use disorders ; Addiction ; Monoamines ; Neuropeptides
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：February, 2014
• 年：2014
• 卷：117
• 期：Complete
• 页码：61-69
• 全文大小：410 K

文摘

Posttraumatic stress disorder (PTSD) co-occurs highly with substance use disorders (SUDs), yet the neurobiological basis for this comorbid relationship remains unclear. PTSD and SUDs result in similar pathological states including impulsive behavior, reward deficiency, and heightened stress sensitivity. Hence, PTSD and SUD may depend on overlapping dysfunctional neurocircuitry. Here we provide a short overview of the relationship between comorbid PTSD and SUD, as well as the potential role of select neurotransmitter systems that may underlie enhanced vulnerability to drug abuse in the context of PTSD.