Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice
Mice exposed to chronic nicotine treatment expressed signs of anxiolysis/depression.
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These mice presented a slighty increased plasma corticosterone concentration.
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Mice exposed to acute nicotine withdrawal expressed signs of anxiety/depression.
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These mice presented a remarkably increased plasma corticosterone concentration.
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Treatment with urocortin 2/3 ameliorated the anxiety and depression-like state developed.
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