Poly(lactic acid) nanoparticles loaded with ursolic acid: Characterization and in vitro evaluation of radical scavenging activity and cytotoxicity

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• 作者：Emilli Antô ; nio ; Osmar dos Reis Antunes Junior ; Isis Souza de Araú ; jo ; Najeh Maissar Khalil ; Rubiana Mara Mainardes ; ^{rubianamainardes@hotmail.com}
• 关键词：Nanoparticles ; Ursolic acid ; Poly(lactic acid) ; Stability ; HOCl ; Cytotoxicity
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：156-166
• 全文大小：1203 K
• 卷排序：71

文摘

Ursolic acid (UA) was nanoencapsulated in PLA nanoparticles. Release of UA from nanoparticles was slow, biphasic and diffusion-controlled. Antioxidant activity of UA was maintained after nanoencapsulation. PLA nanoparticles decreased the hemolytic activity of UA. Nanoparticles exhibited time/concentration dependent cytotoxicity over B16-F10 cells.