Association of frailty with the serine protease HtrA1 in older adults

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Association of frailty with the serine protease HtrA1 in older adults

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作者：Maria Lorenzi^a ; ^{mlorenziusa@yahoo.it" class="auth_mail" title="E-mail the corresponding author} ; ^{labgeriatria.cemi@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Teresa Lorenzi^b ; Emanuele Marzetti^a ; Francesco Landi^a ; Davide L. Vetrano^a ; Silvana Settanni^a ; Manuela Antocicco^a ; Stefano Bonassi^c ; Vanessa Valdiglesias^d ; Roberto Bernabei^a ; Graziano Onder^a
关键词：Frailty ; Immunosenescence ; Inflammation ; High-temperature requirement serine protease A1 ; Biomarkers ; Plasma
刊名：Experimental Gerontology
出版年：2016
出版时间：August 2016
年：2016
卷：81
期：Complete
页码：8-12
全文大小：379 K

文摘

•: Inflamm-aging may be involved in the pathogenesis of frailty.
•: HtrA1 is a secreted multidomain protein with serine protease activity.
•: HtrA1 inhibits signaling of TGF-β proteins with anti-inflammatory properties.
•: Association of HtrA1 with frailty in plasma of older adults has been proven.
•: The assay of HtrA1 levels in plasma has been performed by Elisa method.

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