Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients

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Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients

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作者：Gabriela Jimé ; nez-Valerio¹ ; Mar Martí ; nez-Lozano¹ ; Nicklas Bassani¹ ; August Vidal² ; Marí ; a Ochoa-de-Olza³ ; ⁴ ; Cristina Suá ; rez⁴ ; Xavier Garcí ; a-del-Muro³ ; Joan Carles⁴ ; Francesc Viñ ; als¹ ; ⁵ ; Mariona Graupera⁶ ; Stefano Indraccolo⁷ ; Oriol Casanovas¹ ; ^{ocasanovas@iconcologia.net" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：10 May 2016
年：2016
卷：15
期：6
页码：1134-1143
全文大小：6904 K

文摘

•: Resistance to antiangiogenic therapy involves metabolic symbiosis patterning in RCC
•: mTOR pathway mediates this resistance and mTOR inhibition blocks metabolic symbiosis
•: In patients, antiangiogenics induce symbiotic patterning mostly in resistant tumors
•: mTOR pathway implication is also suggested in patients treated with antiangiogenics

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