Downmodulation of peripheral MOG-specific immunity by pVAXhsp65 treatment during EAE does not reach the CNS

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• 作者：Sofia Fernanda Gonç ; alves Zorzella-Pezavento^a ; Fernanda Chiuso-Minicucci^a ; Thais Graziela Donegá ; Franç ; a^a ; Larissa Lumi Watanabe Ishikawa^a ; Larissa Camargo da Rosa^a ; Priscila Maria Colavite^a ; Camila Marques^b ; Maura Rosane Valerio Ikoma^b ; Cé ; lio Lopes Silva^c ; Alexandrina Sartori^a ; ^{sartori@ibb.unesp.br" class="auth_mail}
• 关键词：Experimental autoimmune encephalomyelitis ; hsp65 ; DNA vaccine ; CD4  ; +  ; CD25  ; +  ; Foxp3  ; + T cells
• 刊名：Journal of Neuroimmunology
• 出版年：15 March, 2014
• 年：2014
• 卷：268
• 期：1-2
• 页码：35-42
• 全文大小：1141 K

文摘

Most of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic effect of a genetic vaccine containing the mycobacterial hsp65 gene on experimental autoimmune encephalomyelitis (EAE). Although pVAXhsp65 was immunogenic for mice with EAE and downmodulated specific cytokine induction by MOG, therapy was not able to decrease clinical severity nor to modify immunologic parameters in the CNS. These results indicate that hsp65, administered as a DNA vaccine, was not therapeutic for EAE.