Bilirubin modulated cytokines, growth factors and angiogenesis to improve cutaneous wound healing process in diabetic rats

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Bilirubin modulated cytokines, growth factors and angiogenesis to improve cutaneous wound healing process in diabetic rats

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作者：Mahendra Ram ; Vishakha Singh ; Sanjay Kumawat ; Vinay Kant ; Surendra Kumar Tandan ; Dinesh Kumar ; ^{dineshks17@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{dineshks17@ivri.res.in" class="auth_mail" title="E-mail the corresponding author}
关键词：Bilirubin ; Cytokines ; Growth factors ; Angiogenesis ; Diabetic rats ; Wound healing
刊名：International Immunopharmacology
出版年：2016
出版时间：January 2016
年：2016
卷：30
期：Complete
页码：137-149
全文大小：2455 K

文摘

•: The percent wound closer was significantly higher in bilirubin-treated rats.
•: mRNA and protein levels of HIF-1α, VEGF, SDF-1α, TGF-β1, IL-10 were significantly higher in bilirubin-treated rats.
•: TNF-α, MMP-9 and IL-1β were mRNA were significantly down regulated in bilirubin-treated rats.
•: The collagen deposition and formation of blood vessels were greater in bilirubin-treated rats.
•: Bilirubin markedly facilitated cutaneous wound healing in diabetic rats.

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