Memory and learning seems to be related to cholinergic dysfunction in the JE rat model

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Memory and learning seems to be related to cholinergic dysfunction in the JE rat model

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作者：Prashant Singh Chauhan^a ; Usha Kant Misra^a ; ^{drukmisra@rediffmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{ukmisra@sgpgi.ac.in" class="auth_mail" title="E-mail the corresponding author} ; Jayantee Kalita^a ; Lalit Pratap Chandravanshi^b ; Vinay Kumar Khanna^b
关键词：Memory ; Learning ; Viral encephalitis ; Muscarinic receptor ; Cognition ; Brain regions
刊名：Physiology & Behavior
出版年：2016
出版时间：15 March 2016
年：2016
卷：156
期：Complete
页码：148-155
全文大小：908 K

文摘

•: Intracerebral inoculation of JEV (3 × 10⁶ pfu/ml) on 12 day Wistar rats.
•: Spatial memory and learning was impaired on 10 and 33 dpi and recovered on 48 dpi.
•: Cholinergic markers were reduced in cortex, hippocampus, striatum, and cerebellum.
•: Correlation between spatial memory and brain cholinergic parameters was found.
•: Transient form of spatial memory impairment was observed in JE infected rats.

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