Nuclear translocation of the cardiac L-type calcium channel C-terminus is regulated by sex and 17β-estradiol

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Nuclear translocation of the cardiac L-type calcium channel C-terminus is regulated by sex and 17β-estradiol

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作者：S. Mahmoodzadeh^a ; ^b ; ^{shokoufeh.mahmoodzadeh@mdc-berlin.de" class="auth_mail" title="E-mail the corresponding author} ; H. Haase^a ; A. Sporbert^c ; T. Rharass^d ; D. Paná ; ková ; ^b ; ^d ; I. Morano^a ; ^b
关键词：Cav1.2 α1C subunit ; Cardiac voltage-gated l-type Ca2 ; + channel alpha subunit (CACNA1C) ; α1C-dCT ; C-terminus fragment of Cav1.2 α1C subunit ; 17β-estradiol ; E2 ; estrogen ; ER ; estrogen receptor ; Cx31.1 ; connexin 31.1 ; cs-FBS ; charcoal stripped fetal bovine serum ; ANF ; atrial natriuretic factor ; ERE ; estrogen response elements
刊名：Journal of Molecular and Cellular Cardiology
出版年：2016
出版时间：August 2016
年：2016
卷：97
期：Complete
页码：226-234
全文大小：2024 K

文摘

•: Distal C-terminus of Ca_v1.2α1C (α1C-dCT) is shuttled into nucleus of cardiomyocytes.
•: We observed a sexual dimorphism in α1C-dCT nuclear localization in cardiomyocytes.
•: Female cardiomyocytes revealed higher nuclear translocation of α1C-dCT than males.
•: Estrogen (E2) regulates the α1C-dCT nuclear shuttling only in male cardiomyocytes.
•: E2-activated ER is needed for nuclear shuttling of α1C-dCT in male cardiomyocytes.

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