Human adipose-derived stem cells ameliorate repetitive behavior, social deficit and anxiety in a VPA-induced autism mouse model

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Human adipose-derived stem cells ameliorate repetitive behavior, social deficit and anxiety in a VPA-induced autism mouse model

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作者：Sungji Ha^a ; ^b ; Hyunjun Park^a ; Usman Mahmood^b ; Jeong Chan Ra^c ; Yoo-Hun Suh^a ; ^{yhsuh@gachon.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Keun-A Chang^a ; ^{kachang74@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Autism spectrum disorder ; Valproic acid ; Adipose-derived stem cell ; Stem cell therapy
刊名：Behavioural Brain Research
出版年：2017
出版时间：15 January 2017
年：2017
卷：317
期：Complete
页码：479-484
全文大小：2190 K

文摘

•: Valproic acid-induced mice model showed core symptoms of autism spectrum disorder (ASD).
•: Human adipose-derived stem cells (hASCs) treatments ameliorate autistic behaviors in VPA-induced ASD model mice.
•: HASCs transplantation rescued altered PTEN expression and p-AKT/AKT ratio in the brains of VPA-induced ASD model mice.
•: HASCs transplantation restored the decreased level of VEGF and IL-10 in the brains of VPA-induced ASD model mice.

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